Malaria
J.M. Greenberg
U.S. Office of Naval Research - Global
223 Old Marylebone Road
London NW1 5TH, U.K.
and
Carnegie Mellon University
Department of Mathematical Sciences
Pittsburgh, PA 15213
and
Ensign Benjamin Heineike
Mathematical Institute
University of Oxford
24-29 St. Giles
Oxford OX1 3LB, U.K.
Abstract: In this paper we model parasite development
in infected blood cells via an age structured population equation
coupled to a boundary condition which yields the number of newly
infected cells at time
of age zero in terms of the number of cells
which burst at time and release daughter parasites into the blood
stream which quickly invade uninfected red blood cells. Sharp
conditions for the existence of nontrivial equilibrium distributions
are established as are conditions for the stability of the trivial
and non-trivial equilibrium distributions. When these conditions are
violated, steady state oscillatory solutions are established and
these are examined.
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